There is currently no FDA-approved medication for methamphetamine use disorder. That does not mean there are no options. For some patients, doctors may consider off-label medications, including the combination of extended-release naltrexone/Vivitrol and bupropion/Wellbutrin, as part of a broader treatment plan.
The evidence for medication is real but modest. These medications are not a cure, and they do not work like Suboxone works for opioid use disorder. The best treatment plan often includes medical follow-up, treatment of depression, anxiety, sleep problems, or alcohol use when present, and behavioral treatment such as contingency management, which uses structured positive reinforcement to support recovery goals.
