Kratom can be addictive for some people. While kratom leaf products are not the same as prescription opioids, kratom contains chemical compounds that can interact with opioid receptors and may lead to tolerance, withdrawal, cravings, or difficulty cutting back.

7-OH, or 7-hydroxymitragynine, is a potent kratom-related compound that is typically present only in trace amounts in natural kratom leaf. Concentrated or chemically enriched 7-OH products are different from traditional kratom leaf products and may carry higher risk, especially when used frequently or in larger amounts.